|
|
|
|
|
|
|
|
|
|
|
|
|
|
Aw: Interessant !!! [Beitrag #224375 ist eine Antwort auf Beitrag #224297] :: Do., 22 März 2012 18:23  
|
f526
Beiträge: 9 Registriert: Februar 2009 Ort: Wien
|
Einer der Prostaglandin blockierenden Substanzen ist auch Latanoprost. Es wird in Form von Augentropfen zur Senkung des Augeninnendrucks eingesetzt.
Offenbar gibt es tatsächlich auch schon Studien zur Behandlung der androgenetischen Alopezie mit diesem Mittel.
siehe www.haarerkrankungen.de/aktuelles/haarsinglenewsmeldung.php?newsid=20111016
|
|
Den Beitrag einem Moderator melden
 
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Aw: Interessant !!! [Beitrag #226540 ist eine Antwort auf Beitrag #224297] :: Mi., 11 April 2012 19:56
|
|
|
"prostaglandins are dysregulated in AGA, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2α. Agents such as aspirin, which inhibit upstream prostaglandin synthesis enzymes (PTGS1 and PTGS2), have minimal effects on hair growth because of likely equally decreased production of PGE2 and PGD2."
"highly testosterone-responsive transcript, which further suggests its importance in AGA. PGD2 is thought to play a central role in male gonadal sex determination and is highly expressed in male genitalia. Similarly, Ptgds expression in the heart is regulated by estrogen. Estrogen leads to increases in 15-dPGJ2 levels in the uropygial gland."
"Given the androgens are aromatized into estrogens, these results may be relevant to hair growth and alopecia in men Thus, these or similar pathways might be conserved in the skin and suggest that sex hormone regulation of Ptgds may contribute to the pathogenesis of AGA"
"minoxidil alters potassium channel kinetics, it is also known to increase production of PGE2. Given the decreased amount of PGE2 present in bald scalp versus haired scalp, minoxidil may normalize PGE2 levels. Future studies should address whether minoxidil can concomitantly decrease PGD2 levels and thus normalize multiple prostaglandin species as a mechanism to improve AGA."
"supplemental PGE2 could be therapeutic. By correcting its deficiency and increasing its level in bald scalp, the inhibitory effects of PGD2 may be overcome. Analogs of PGF2α, which are already FDA-approved to promote eyelash growth, should also have similar effects on the scalp and are currently in clinical trials for this indication. Once issues of delivery, dosing, and safety are addressed, additional agonists and antagonists of prostaglandin pathways should become available.
"The K14-Ptgs2 transgenic mouse model, which phenocopies AGA, may assist in screening novel therapeutic agents. Ultimately, multiple mechanisms may be responsible for hair loss in AGA. Inhibiting PGD2 may prevent miniaturization and provide benefit to those in the process of balding; however, it is unclear whether men who are already bald will regrow hair."
Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia 2012
Luis A. Garza, Yaping Liu, Zaixin Yang, Brinda Alagesan, John A. Lawson, Scott M.Norberg, Dorothy E. Loy, Tailun Zhao, Hanz B. Blatt, David C. Stanton, Lee Carrasco,Gurpreet Ahluwalia, Susan M. Fischer, Garret A. FitzGerald, and George Cotsarelis
|
|
Den Beitrag einem Moderator melden
|
|
|
|
|
|
Suche
Hilfe
Mitglieder
Registrieren
Anmelden
Startseite
Video Schuppen / seborrhoisches Ekzem
