Haarausfall - Allgemeines Forum : Studien Finasterid » Basaria et al. (2016). Characteristics of Men Who Report Persistent Sexual Symptoms....

Basaria et al. (2016). Characteristics of Men Who Report Persistent Sexual Symptoms.... [Beitrag #375038] :: Mi., 19 Oktober 2016 19:41

Link: http://press.endocrine.org/doi/abs/10.1210/jc.2016-2726

Abstract

Context:
Some men who use finasteride for hair loss report persistent sexual and other symptoms after discontinuing finasteride therapy.

Objective:
To determine whether these persistent symptoms after discontinuation of finasteride use are due to androgen deficiency, decreased peripheral androgen action, or persistent inhibition of steroid 5α-reductase (SRD5A) enzymes.

Participants:
Finasteride-users, who reported persistent sexual symptoms after discontinuing finasteride (group 1); age-matched finasteride-users who did not report sexual symptoms (group 2); and healthy men who had never used finasteride (group 3).

Outcomes:
Sexual function, mood, affect, cognition, hormone levels, body-composition, functional magnetic resonance imaging (fMRI) response to sexually and affectively-valenced stimuli, nucleotide sequences of androgen receptor (AR), SRD5A1 and SRD5A2; expression levels of androgen-dependent genes in skin

Setting:
Academic medical center

Results:
Symptomatic finasteride-users were similar in body composition, strength, and nucleotide sequences of AR, SRD5A1 and SRD5A2 genes to asymptomatic finasteride-users and nonusers. Symptomatic finasteride-users had impaired sexual function, higher depression scores, a more negative affectivity balance, and more cognitive complaints than men in groups 2 and 3, but had normal objectively-assessed cognitive function. Testosterone, DHT, 5α-androstane-3α,17|gb-diol glucuronide, testosterone-to-DHT and androsterone glucuronide-to-etiocholanolone glucuronide ratios, and markers of peripheral androgen action, and expression levels of AR-dependent genes in skin did not differ among groups. fMRI BOLD responses to erotic and nonerotic stimuli revealed abnormal function in brain circuitry linked to sexual arousal and major depression.

Conclusions:
We found no evidence of androgen deficiency, decreased peripheral androgen action, or persistent peripheral inhibition of SRD5A in men with persistent sexual symptoms after finasteride use. Symptomatic finasteride-users revealed depressed mood and fMRI findings consistent with those observed in depression.

[Aktualisiert am: Mi., 19 Oktober 2016 19:53]

Fin seit 2009 (1.25mg/Woche); Minox seit 2011; Ket seit 2012 (1%/Tag)
Abgesetzt: Dut 2011-2017 (0.05mg/Woche); RU 2014-2017 (3%/Tag)

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