Haarausfall - Allgemeines Forum : Studien Finasterid » Ali et al. (2015). Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with...

Ali et al. (2015). Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with... [Beitrag #375061] :: Mi., 19 Oktober 2016 21:31

Link: http://onlinelibrary.wiley.com/doi/10.1002/phar.1612/full

Abstract

Study Objective:
Finasteride, a 5α-reductase inhibitor, is marketed in a low dose (1 mg) as a popular therapy for androgenic alopecia in young men. As case reports and small surveys have suggested a link between persistent sexual dysfunction (SD) and suicidal ideation (SI) with low-dose finasteride, the aim of this study was to detect signals of SD and SI secondary to low-dose finasteride use in young men.

Design:
Retrospective pharmacovigilance disproportionality analysis.

Data Source:
United States Food and Drug Administration Adverse Event Reporting System (FAERS) database.

Measurements and Main Results:
Low-dose finasteride-related adverse event reports for men aged 1845 years that were submitted to the FAERS between 1998 and 2013 were retrieved. Multi-item Gamma Poisson Shrinker disproportionality analysis was applied to calculate the empirical Bayes geometric mean (EBGM) and corresponding 95% confidence interval (CI) as an association metric between low-dose finasteride and the events of interest. Signals were defined as associations with thresholds of a CI lower limit of 2.0 or greater. Medical Dictionary for Regulatory Activities Preferred Terms denoting to SD and SI were identified to reflect the outcome of interest. In total, of 4910 reports, 577 persistent SD and 39 SI adverse event reports (11.8% and 7.9%, respectively) were identified for young men using low-dose finasteride; 34 (87.2%) of the 39 men with SI also experienced SD. The majority of these events were serious (e.g., contributed to the patient's death, hospitalization, or disability). Low-dose finasteride was associated with more than expected reporting of SD in young men compared with reporting of these events with all other drugs within the database (EBGM 28.0, 95% CI 26.130.0). Disproportional reporting in SI events was noted, although it did not reach signal threshold (EBGM 1.72; 95% CI 1.312.23). Among serious SD events, 43% led to disability; 28% required medical intervention, including hospitalization; and 5% were life-threatening. Six fatal SD reports were identified.

Conclusion:
Persistent SD might be a potential risk of low-dose finasteride for androgenic alopecia therapy in young men, and this risk might contribute to SI. Our findings provide a strong hypothesis for pharmacoepidemiologic studies to further examine this association.

Fin seit 2009 (1.25mg/Woche); Minox seit 2011; Ket seit 2012 (1%/Tag)
Abgesetzt: Dut 2011-2017 (0.05mg/Woche); RU 2014-2017 (3%/Tag)

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Aw: Ali et al. (2015). Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with... [Beitrag #375557 ist eine Antwort auf Beitrag #375061] :: Fr., 28 Oktober 2016 16:59

http://www.sciencedirect.com/science/article/pii/S0950351X98804783

aus
https://www.hairlosstalk.com/interact/threads/do-not-stop-finasteride-cold-turkey-a-strong-argument-to-taper-to-very-low-doses.88299/

ich frag mich warum hier immer noch welche dieses Dreckszuegs nehmen?
war grade wieder in der Uniklinik 5 Tage, die geben mir keine
Hoffnung mehr das ich jemals wieder Gesund werde.

mein Körper zerstört sich langsam immer mehr,mein Körper
ist voller Entzündungen.
sieht man auch in dem Video
https://www.youtube.com/watch?v=R_ivSvW6AhU&feature=youtu.be

Vorerst nichts mehr
Meine Devise:
Irgendwann wirkt kein Mittel mehr, aber man hat sich die
Gesundheit ruiniert.

http://www.askapatient.com/viewrating.asp?drug=20788&
name=PROPECIA
http://www.zeemaps.com/view?group=976852&x=-95.635405&y=54.312212&z=13

Meine Haarausfall-Geschichte im FOXI-Thread

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Aw: Ali et al. (2015). Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with... [Beitrag #377055 ist eine Antwort auf Beitrag #375061] :: Mi., 23 November 2016 11:36

https://tonic.vice.com/en_us/article/the-medical-mystery-behind-americas-best-selling-hair-loss-drug

Vorerst nichts mehr
Meine Devise:
Irgendwann wirkt kein Mittel mehr, aber man hat sich die
Gesundheit ruiniert.

http://www.askapatient.com/viewrating.asp?drug=20788&
name=PROPECIA
http://www.zeemaps.com/view?group=976852&x=-95.635405&y=54.312212&z=13

Meine Haarausfall-Geschichte im FOXI-Thread

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Aw: Ali et al. (2015). Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with... [Beitrag #377057 ist eine Antwort auf Beitrag #377055] :: Mi., 23 November 2016 11:46

Bei der Verbindung von Fin mit Depressionen sollte meines Erachtens die berühmte "Huhn oder Ei"-Frage nicht vernachlässigt werden.

"Der Plural von 'Anekdote' ist nicht 'Evidenz'."
- Alan I. Leshner

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Aw: Ali et al. (2015). Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with... [Beitrag #377058 ist eine Antwort auf Beitrag #375061] :: Mi., 23 November 2016 12:02

Leute mit niedrigen Vitamin D3 Spiegeln haben bei Fin und Dut ein erhöhtes Risiko für Depressionen. Dut kann das viel stärker auslösen.

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