Haarausfall - Allgemeines Forum : Gentherapie » Hagenaars et al. (2017). Genetic prediction of male pattern baldness

Hagenaars et al. (2017). Genetic prediction of male pattern baldness [Beitrag #393083] :: So., 23 Juli 2017 18:54

Open access unter:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006594

Abstract
Male pattern baldness can have substantial psychosocial effects, and it has been phenotypically linked to adverse health outcomes such as prostate cancer and cardiovascular disease. We explored the genetic architecture of the trait using data from over 52,000 male participants of UK Biobank, aged 4069 years. We identified over 250 independent genetic loci associated with severe hair loss (P<5x10-8). By splitting the cohort into a discovery sample of 40,000 and target sample of 12,000, we developed a prediction algorithm based entirely on common genetic variants that discriminated (AUC = 0.78, sensitivity = 0.74, specificity = 0.69, PPV = 59%, NPV = 82%) those with no hair loss from those with severe hair loss. The results of this study might help identify those at greatest risk of hair loss, and also potential genetic targets for intervention.

edit:
wow! Der von ihnen entwickelte "prediction algo" ist eine multiple lineare regression? naja, immerhin...

[Aktualisiert am: So., 23 Juli 2017 19:00]

Fin seit 2009 (1.25mg/Woche); Minox seit 2011; Ket seit 2012 (1%/Tag)
Abgesetzt: Dut 2011-2017 (0.05mg/Woche); RU 2014-2017 (3%/Tag)

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