Haarausfall - Allgemeines Forum : Studien Finasterid » Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: bette

Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: bette [Beitrag #124562] :: So., 08 Juni 2008 14:16

Br J Dermatol. 2008 May;158(5):1121-4. Epub 2008 Mar 20.Click here to read Links
Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under 26 years old.
Camacho FM, García-Hernández MJ, Fernández-Crehuet JL.

Department of Dermatology, Hospital Universitario Virgen Macarena, Avda. Dr Fedriani s/n. 41071 Sevilla, Spain. camachodp@medynet.com

BACKGROUND: Finasteride is a 5alpha-reductase inhibitor that has proved to be an effective treatment for men with androgenetic alopecia. OBJECTIVES: To investigate the hormonal influence of finasteride 1 mg daily on hormonal levels and hair growth in men of different ages and with different degrees of alopecia according to the Hamilton-Norwood scale. METHODS: Two hundred and seventy men aged 14-58 years with male androgenetic alopecia III-VI Hamilton-Norwood score (II-III Ebling score) were treated with finasteride 1 mg daily. Steroid hormone (free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone-sulphate, delta4-androstenedione, 17-hydroxyprogesterone), prostate-specific antigen (PSA) and sebum levels, and trichogram changes were determined at baseline, and at 6 and 12 months of treatment. RESULTS: According to significant hormonal statistical analysis, the patients were divided by age (up to or over 26 years). In the group of patients<or=26 years, higher levels of 5alpha-dihydrotestosterone were found at the beginning of the treatment, but there was a 50% decrease between the onset of treatment and month 12, particularly noticeable at 6 months (P<0.05) of treatment, running parallel to an improvement of the alopecia and an increase of anagen hairs in the trichogram. At 1 year, PSA levels decreased 20%, particularly in patients>26 years. No variations in sebum levels were observed. CONCLUSIONS: High levels of 5alpha-dihydrotestosterone in patients<or=26 years at the beginning of treatment are a predictive factor of good response to treatment with finasteride 1 mg daily.

bessere chancen also, wenn man jung ist und nen "schlechtes hormonelles blatt" hat, was mit fin zu erreichen.

--ca. 0,2 mg Fin/d, seit 05/14, KET, Salix Alba Shampoo (bei SE)--
[Abgesetzt: 0,3 mg Fin/d (1/14 - 5/14), 0,4 mg Fin/d (3/12-01/14), 0,7 mg Fin/d (06/09 - 3/12), 1,25mg Fin (11/05-06/09), diverse NEMs]

Den Beitrag einem Moderator melden