"Our characterization of the relationship between minoxidil and AR showed that minoxidil interferes with AR-related functions, decreasing AR transcriptional activity, reducing expression of targets at the protein level, and suppressing AR-positive LNCaP cell growth. Furthermore, our mechanistic studies showed that the suppressive effect of minoxidil on AR-related functions reflected its ability to directly bind to the AR; interfere with AR-peptide, AR-coregulator and AR N-C interactions; and reduce AR protein stability."
Minoxidil may suppress androgen receptor-related functions